Stromelysin‐1(MMP3) Worsens the Neurovascular Injury in Hyperglycemic Stroke.
نویسندگان
چکیده
منابع مشابه
Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke
Ischemic stroke is a leading cause of death and disability, and the mechanisms involved in the neurovascular deterioration after stroke are multifactorial and highly complicated. Hyperglycemia is one of the factors that worsen the neurovascular injury, and it is considered an independent predictor of poor clinical outcomes after stroke. Almost 50% of patients with acute ischemic stroke were pre...
متن کاملNeurovascular proteases in brain injury, hemorrhage and remodeling after stroke.
Matrix metalloproteinases (MMPs) mediate tissue injury during acute stroke. Clinical data show that elevated MMPs in plasma of stroke patients may correlate with outcomes, suggesting its use as a biomarker. MMP-9 signal has also been detected in clinical stroke brain tissue samples. Because tissue plasminogen activator can upregulate MMPs via lipoprotein receptor signaling, these neurovascular ...
متن کاملCerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke.
The consequences of cerebrovascular disease are among the leading health issues worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the vascular component of other forms of neurological dysfunction and degeneration. Both forms of vascular disease are driven by diverse risk factors, with hypertension as the leading contributor. Despite the importance of neurov...
متن کاملLetter by Shao and Zhang Regarding Article, "Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke".
Letter by Shao and Zhang Regarding Article, “Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke” To the Editor: We read with interest the recent study by Hafez et al titled “Matrix Metalloprotease 3 Exacerbates Hemorrhagic Trans formation and Worsens Functional Outcomes in Hyperglycemic Stroke.” The authors performed a study ...
متن کاملResponse to Letter Regarding Article, "Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke".
BACKGROUND AND PURPOSE Acute hyperglycemia worsens the clinical outcomes and exacerbates cerebral hemorrhage after stroke. The mediators of hemorrhagic transformation (HT) in hyperglycemic stroke are not fully understood. Matrix metalloproteinase 3 (MMP3) plays a critical role in the tissue-type plasminogen activator-induced HT. However, the role of MMP3 in exacerbating the HT and worsening the...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.1169.6